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Article

Different hematological phenotypes caused by the interaction of triplicated alpha-globin genes and heterozygous beta-thalassemia.

American journal of hematology - 1 Jun 1997

Camaschella C, Kattamis A C, Petroni D, Roetto A, Sivera P, Sbaiz L, Cohen A, Ohene-Frempong K, Trifillis P, Surrey S, Fortina P

Abstract excerpt

The pathophysiology and clinical severity of beta-thalassemia are related to the degree of alpha/non-alpha-chain imbalance. A triplicated alpha-globin gene locus can exacerbate effects of excess alpha-chains caused by a defective beta-globin gene, although this is not observed in all cases. Extensive studies on this condition are lacking. We report a group of 17 patients who are heterozygous for both the alpha...

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Identifiers

PMID: 9209003
DOI: 10.1002/(sici)1096-8652(199706)55:2<83::aid-ajh6>3.0.co;2-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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