Article
The triplicated alpha-globin gene locus in beta-thalassaemia heterozygotes: clinical, haematological, biosynthetic and molecular studies.
British journal of haematology - 1 Dec 1996
Traeger-Synodinos J, Kanavakis E, Vrettou C, Maragoudaki E, Michael T, Metaxotou-Mavromati A, Kattamis C
Abstract excerpt
Excess alpha-globin chains play a major role in the pathophysiology of homozygous beta-thalassaemia. In beta-thalassaemia carriers a minor effect of alpha-globin chain excess is reflected in a minimal or mild anaemia without clinical symptoms. Factors that increase alpha-chain excess in heterozyg...
Topics
- Adult
- Child
- Child, Preschool
- Female
- Genotype
- Globins
- Heterozygote
- Homozygote
- Humans
- Male
- Multigene Family
- Mutation
- Pedigree
- beta-Thalassemia