Article
Screening for ESR mutations in breast and ovarian cancer patients.
Human mutation - 1 Jan 1997
Anderson T I, Wooster R, Laake K, Collins N, Warren W, Skrede M, Elles R, Tveit K M, Johnston S R, Dowsett M, Olsen A O, Møller P, Stratton M R, Børresen-Dale A L
Abstract excerpt
In the present study, leukocyte DNA from 143 patients with familial clustering of breast and/or ovarian cancer and tumour DNA from 96 breast carcinomas were screened for base mutations in the estrogen receptor gene (ESR). Three patients with a family history of cancer were carrying a Gly160Cys germline substitution. This alteration was also detected in eight (four females and four males) of 729 controls (366...
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