Article
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Genetics - 1 Jun 1999
Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B
Abstract excerpt
Selection of mutator alleles, increasing the mutation rate up to 10, 000-fold, has been observed during in vitro experimental evolution. This spread is ascribed to the hitchhiking of mutator alleles with favorable mutations, as demonstrated by a theoretical model using selective parameters corresponding to such experiments. Observations of unexpectedly high frequencies of mutators in natural isolates suggest that...
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