Article
Mutators, population size, adaptive landscape and the adaptation of asexual populations of bacteria.
Genetics - 1 Jun 1999
Tenaillon O, Toupance B, Le Nagard H, Taddei F, Godelle B
Abstract excerpt
Selection of mutator alleles, increasing the mutation rate up to 10, 000-fold, has been observed during in vitro experimental evolution. This spread is ascribed to the hitchhiking of mutator alleles with favorable mutations, as demonstrated by a theoretical model using selective parameters corres...
Topics
- Adaptation, Physiological
- Alleles
- Bacteria
- Biological Evolution
- Escherichia coli
- Gene Frequency
- Genetics, Population
- Genotype
- Models, Genetic
- Mutation
- Selection, Genetic