Article
Deletion of c-myb exon 9 induced by insertion of repeats.
Oncogene - 12 Jun 1997
Shinagawa T, Ishiguro N, Horiuchi M, Matsui T, Okada K, Shinagawa M
Abstract excerpt
A simple repeat was found to be inserted into exon 9 of the c-myb gene in three out of 20 bovine T lymphomas. The repeat was composed of multiple copies of a 12-nucleotide motif and had no significant homology to the sequences reported so far. Tumor cells containing the repeat expressed two kinds of c-myb mRNA: (1) are that included the repetitive sequence in exon 9, and (2) are that lacked the whole sequence of...
Topics
- Animals
- Base Sequence
- COS Cells
- Cattle
- DNA Transposable Elements
- Exons
- Lymphoma, T-Cell
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myb
- RNA Precursors
- Repetitive Sequences, Nucleic Acid
- Sequence Deletion
- Trans-Activators
- Transcription, Genetic
- Tumor Cells, Cultured