Article
Remote conformational effects of the Gly-62 --> Leu mutation of the Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli and its second-site suppressor mutation.
Biochemistry - 10 Jun 1997
Kimura T, Sawai T, Yamaguchi A
Abstract excerpt
Substitution of Gly-62 of the Tn10-encoded metal-tetracycline/H+ antiporter caused a functional defect corresponding to the volume of the substituent [Yamaguchi, A., Someya, Y., and Sawai, T. (1992) J. Biol. Chem. 267, 19155-19162]. A spontaneous revertant exhibiting tetracycline resistance was isolated from Escherichia coli cells carrying the tetA(B) gene encoding the G62L mutation. The revertant showed a...
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