Article
Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi.
FEBS letters - 12 May 1997
Jäckel M, Witt C, Antonova O, Curdt I, Labeit S, Jockusch H
Abstract excerpt
The gene for titin, a 4MDa myofibrillar protein, was analysed in golden hamster DNAs from different sources, using human cDNA probes and PCR. In the DNA from the BHK-21-Bi subline of baby hamster kidney cells, extended sequences coding for Z-line associated domains were missing, indicating a deletion that renders titin non-functional. These sequences were present in the original BHK-21 line and in hamster DNAs....
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