Article
Progesterone receptor (PR) inhibits expression of insulin-like growth factor-binding protein-1 (IGFBP-1) in human endometrial cell line HEC-1B: characterization of the inhibitory effect of PR on the distal promoter region of the IGFBP-1 gene.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1997
Gao J, Tseng L
Abstract excerpt
Progestin has been shown to have both stimulatory and inhibitory effects on the expression of insulin-like growth factor binding protein-1 (IGFBP-1) in human endometrial cells. In this study, progestin was found to reduce levels of secreted IGFBP-1 and IGFBP-1 messenger RNA and IGFBP-1 promoter a...
Topics
- Base Sequence
- Cell Line
- Endometrium
- Female
- Gene Expression Regulation, Developmental
- Gonanes
- Hormone Antagonists
- Humans
- Insulin-Like Growth Factor Binding Protein 1
- Medroxyprogesterone Acetate
- Mutation
- Progesterone Congeners
- Promoter Regions, Genetic
- RNA, Messenger