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Article

Imprint switch mechanism indicated by mutations in Prader-Willi and Angelman syndromes.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 1997

Kelsey G, Reik W

Abstract excerpt

Genomic imprinting is an epigenetic mechanism resulting in the preferential expression of the maternal or paternal alleles of a specific subset of genes in the mammalian genome. A key but relatively unexplored question is how imprints are established in the germline. New observations on two classical imprinting disorders, the Prader-Willi (PWS) and Angelman (AS) syndromes, offer the first genetic insight into...

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Identifiers

PMID: 9174400
DOI: 10.1002/bies.950190502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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