Article
Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains.
Neurobiology of disease - 1 Dec 1994
Persichetti F, Srinidhi J, Kanaley L, Ge P, Myers R H, D'Arrigo K, Barnes G T, MacDonald M E, Vonsattel J P, Gusella J F
Abstract excerpt
CAG repeat expansion in the Huntington's disease gene (HD) was examined in postmortem brains from 310 clinically diagnosed and 15 'at risk' individuals. Presence of an expanded CAG allele (>37 units) was the cause of the disorder in almost all cases (307 of 310). Despite a diversity of reporting clinicians, neurological and psychiatric onset and age at death all displayed significant inverse correlations with CAG...
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