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Depletion of Glutathione during Bovine Oocyte Maturation Reversibly Blocks the Decondensation of the Male Pronucleus and Pronuclear Apposition during Fertilization1

1 Jun 1997

Abstract excerpt

Oocyte-produced glutathione (the tripeptide gamma-glutamyl-cysteinyl-glycine; GSH) has been implicated in the reduction of disulfide bonds in the sperm nucleus during fertilization and thus in the development of the male pronucleus (PN). In this study, we show that the depletion of endogenous glutathione by 10 mM buthionine sulfoximine (BSO; specific inhibitor of GSH synthesis) during bovine oocyte maturation (24...

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PMID: 9166704
DOI: 10.1095/biolreprod56.6.1503

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