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Glutathione Oxidation is Associated with Altered Microtubule Function and Disrupted Fertilization in Mature Hamster Oocytes1

1 Dec 1997

Abstract excerpt

We hypothesized that depletion of glutathione (GSH) with diamide, a relatively specific GSH oxidant, may alter the meiotic spindle apparatus in mature hamster oocytes. Immunofluorescent analysis of oocytes exposed to diamide for 1.5 or 3 h revealed time- and concentration-dependent disruption of spindle morphology accompanied by chromosome clumping. In oocytes first cultured in diamide for 1.5 h and then in...

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PMID: 9408248
DOI: 10.1095/biolreprod57.6.1413

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Glutathione Oxidation is Associated with Altered Microtubule Function and Disrupted Fertilization in Mature Hamster Oocytes1PMID 9408248Read ↗

Glutathione (GSH) concentrations vary with the cell cycle in maturing hamster oocytes, zygotes, and pre‐implantation stage embryosSemantic proximity Read ↗

Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageingSemantic proximity Read ↗

Antioxidant therapy counteracts the disturbing effects of diamide and maternal ageing on meiotic division and chromosomal segregation in mouse oocytesSemantic proximity Read ↗

Depletion of Glutathione during Bovine Oocyte Maturation Reversibly Blocks the Decondensation of the Male Pronucleus and Pronuclear Apposition during Fertilization1Semantic proximity Read ↗

Carbendazim (MBC) disrupts oocyte spindle function and induces aneuploidy in hamsters exposed during fertilization (meiosis II)Semantic proximity Read ↗

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rateSemantic proximity Read ↗

Resveratrol attenuates doxorubicin-induced meiotic failure through inhibiting oxidative stress and apoptosis in mouse oocytesSemantic proximity Read ↗

Melatonin protects oocytes from cadmium exposure-induced meiosis defects by changing epigenetic modification and enhancing mitochondrial morphology in the mouseSemantic proximity Read ↗

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