Article
Detection of heterozygous C8 beta deficiency by PCR in a healthy Italian population.
Experimental and clinical immunogenetics - 1 Jan 1996
Bellavia D, Schneider P M, Rittner C, Malfitano G, Kaufmann T J, Brai M
Abstract excerpt
In Italy a rather high number of homozygotes with late complement component defects has been found among patients with meningococcal disease. It seems that clinical manifestations of meningococcal disease are less severe in patients with complement deficiency than in normal individuals. This situation could even be more evident in the heterozygous carriers for whom a selective advantage is discussed. In this...
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