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Prevention of motoneuron death by adenovirus-mediated neurotrophic factors

1 May 1997

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motoneurons, and has no effective treatment. Experimental studies in rodents have shown that motoneurons respond to a variety of molecules including brain-derived neurotrophic factor (BDNF). and the glial-cell line-derived neurotrophic factor (GDNF). Here we investigated the neuroprotective effect of...

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PMID: 9160251
DOI: 10.1002/(sici)1097-4547(19970501)48:3<281::aid-jnr11>3.0.co;2-4

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