Article
Effects of penicillin-binding protein 4 overproduction in Staphylococcus aureus.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1996
Henze U U, Roos M, Berger-Bächi B
Abstract excerpt
The pbp4 gene of a Staphylococcus aureus strain selected stepwise in vitro for growth on increasing concentrations of penicillin and of its susceptible parent strain showed overall identity except in the promoter region. In the mutant a deletion upstream of the pbp4 structural gene removed 90 nucleotides (nt) that were framed by a 12 nt inverted repeat. This deletion occurred in step 4 of the in vitro selection...
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