[Approval of HIV protease inhibitors as the AIDS therapeutics of next generation].

Abstract excerpt

The long-term usages of reverse transcriptase inhibitors as anti-HIV drugs have induced serious side effects and emergence of resistant viruses. To overcome these problems, combination therapies are expected to be effective. Under such circumstances, HIV protease inhibitors have been rationally designed and synthesized based on the substrate transition state concept. HIV protease inhibitors act at the exact point...

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