Article
No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease.
Neurology - 1 May 1997
Murphy G M, Sullivan E V, Gallagher-Thompson D, Thompson L W, van Duijn C M, Forno L S, Ellis W G, Jagust W J, Yesavage J, Tinklenberg J R
Abstract excerpt
The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in AD subjects with the apolipoprotein E (APOE) epsilon4 allele. We examined ACT and APOE genotypes in a sample of 160 subjects with probable AD and in 102 elderly control subjects. ACT A allele frequencies were similar in AD subjects (0.503) and elderly...
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