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Article

Retinal pigment epithelium abnormalities in mice with adenomatous polyposis coli gene disruption.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 May 1997

Marcus D M, Rustgi A K, Defoe D, Brooks S E, McCormick R S, Thompson T P, Edelmann W, Kucherlapati R, Smith S

Abstract excerpt

OBJECTIVE: To examine eyes from mice with targeted adenomatous polyposis coli (APC) gene disruption to determine if retinal pigment epithelium (RPE) abnormalities replicate the human counterpart. METHODS: Thirty-two eyes from 16 mice heterozygous for APC gene disruption (chain-termination mutation in codon 1638 of exon 15) and 12 control eyes were examined by light microscopy. RESULTS: Fifteen of 32 eyes from 12...

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Source

Identifiers

PMID: 9152133
DOI: 10.1001/archopht.1997.01100150647013

Genes

RPE
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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