Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

1 Jun 1997

Abstract excerpt

During human cytomegalovirus (HCMV) infection, the promoters for the classical NF-kappaB subunits (p65 and p105/p50) are transactivated. Previously, we demonstrated that the viral immediate-early (IE) proteins (IE1-72, IE2-55, and IE2-86) were involved in this upregulation. These viral factors alone, however, could not account for the entirety of the increased levels of transcription. Because one of the hallmarks...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to RNA regulation and disease
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9151857
DOI: 10.1128/jvi.71.6.4638-4648.1997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promotersPMID 9151857Read ↗

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promotersSemantic proximity Read ↗

Two Sp1/Sp3 Binding Sites in the Major Immediate-Early Proximal Enhancer of Human Cytomegalovirus Have a Significant Role in Viral ReplicationSemantic proximity Read ↗

Activation of the NF-κB Pathway in Human Cytomegalovirus-Infected Cells Is Necessary for Efficient Transactivation of the Major Immediate-Early PromoterSemantic proximity Read ↗

The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infectionSemantic proximity Read ↗

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains.Semantic proximity Read ↗

The Immediate Early Gene 1 Product of Human Cytomegalovirus Is Sufficient for Up-Regulation of Interleukin-8 Gene ExpressionSemantic proximity Read ↗

Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elementsSemantic proximity Read ↗

The Activator Protein 1 Binding Motifs within the Human Cytomegalovirus Major Immediate-Early Enhancer Are Functionally Redundant and Act in a Cooperative Manner with the NF-κB Sites during Acute InfectionSemantic proximity Read ↗

Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling PathwaysSemantic proximity Read ↗

Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cellsSemantic proximity Read ↗

The p38 Mitogen-activated Kinase Pathway Regulates the Human Interleukin-10 Promoter via the Activation of Sp1 Transcription Factor in Lipopolysaccharide-stimulated Human MacrophagesSemantic proximity Read ↗

Different members of the Sp1 multigene family exert opposite transcritional regulation of the long terminal repeat of HIV-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.