Article
Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.
Virology - 14 Apr 1997
Rico-Hesse R, Harrison L M, Salas R A, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa M T, Nogueira R M, da Rosa A T
Abstract excerpt
The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate...
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