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Article

Apolipoprotein E epsilon 4 allele and pupillary response to tropicamide.

The American journal of psychiatry - 1 May 1997

Higuchi S, Matsushita S, Hasegawa Y, Muramatsu T, Arai H, Hayashida M

Abstract excerpt

OBJECTIVE: This study was designed to investigate in cognitively normal subjects the possible association between hypersensitive pupil dilation response to the cholinergic antagonist tropicamide and the presence of the apolipoprotein E epsilon 4 (APOE4) allele, a well-defined genetic risk factor for Alzheimer's disease. METHOD: The authors measured tropicamide-induced changes in pupil area in 44 cognitively...

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Identifiers

PMID: 9137131
DOI: 10.1176/ajp.154.5.694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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