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Article

Nif1, a novel mitotic inhibitor in Schizosaccharomyces pombe.

The EMBO journal - 17 Mar 1997

Wu L, Russell P

Abstract excerpt

In Schizosaccharomyces pombe, the activity of the M-phase-inducing Cdc2/Cdc13 cyclin-dependent kinase is inhibited by Wee1 and Mik1 tyrosine kinases, and activated by Cdc25 and Pyp3 tyrosine phosphatases. Cdc2/Cdc13 activity is also indirectly regulated by the approximately 70 kDa Nim1 (Cdrl) serine/threonine kinase, which promotes mitosis by inhibiting Wee1 via direct phosphorylation. To understand better the...

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Identifiers

PMID: 9135149
DOI: 10.1093/emboj/16.6.1342
PMCID: PMC1169731

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Related research

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Nif1, a novel mitotic inhibitor in Schizosaccharomyces pombe.PMID 9135149Read ↗

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Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe.Semantic proximity Read ↗

A NIMA homologue promotes chromatin condensation in fission yeast.Semantic proximity Read ↗

Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe: genetic interactions of mutations.Semantic proximity Read ↗

The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Evidence for a NIMA-like mitotic pathway in vertebrate cells.Semantic proximity Read ↗

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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.Semantic proximity Read ↗

mik1(+) G1-S transcription regulates mitotic entry in fission yeast.Semantic proximity Read ↗

Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.Semantic proximity Read ↗

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