Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis.

doi:10.1002/art.1780400406

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Article

Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis.

Arthritis and rheumatism - 1 Apr 1997

Starkebaum G, Loughran T P, Gaur L K, Davis P, Nepom B S

Abstract excerpt

OBJECTIVE: Patients with chronic clonal proliferation of large granular lymphocytes (LGL leukemia) often have splenomegaly, neutropenia, and rheumatoid arthritis (RA), thereby resembling the manifestations observed in patients with Felty's syndrome. The present study sought to determine whether p...

Topics

Arthritis, Rheumatoid
Clone Cells
Cohort Studies
Felty Syndrome
Genotype
HLA-DR4 Antigen
Humans
Immunogenetics
Leukemia, Lymphoid
Prospective Studies

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