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Article

Contrasting effects of PNA invasion of the chimeric DMMYC gene on transcription of its myc and PVT domains.

Oncology research - 1 Jan 1997

Boffa L C, Carpaneto E M, Mariani M R, Louissaint M, Allfrey V G

Abstract excerpt

A peptide nucleic acid (PNA) complementary to a unique DNA sequence in the second exon of the human myc proto-oncogene was tested for its effects on transcription in colonic adenocarcinoma cells in which myc had been amplified and rearranged. A prominent rearrangement in this human cell line (COLO320-DM) involves the insertion of exon 1 of the PVT gene, which is normally located 57 kb downstream, into the first...

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PMID: 9112259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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