Article
Characterization of an unstable variant (BChE115D) of human butyrylcholinesterase.
Pharmacogenetics - 1 Feb 1997
Primo-Parmo S L, Lightstone H, La Du B N
Abstract excerpt
An unstable variant of human butyrylcholinesterase (BChE) is described in four apparently unrelated individuals sensitive to succinylcholine. Sequencing of genomic DNA revealed a single nucleotide substitution which results in the replacement of amino acid residue Gly115 by Asp. This variant can be recognized by its increased instability under extremes of temperature such as heating and also freezing and thawing,...
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