Article
A wat1 mutant of fission yeast is defective in cell morphology.
Molecular & general genetics : MGG - 26 Mar 1997
Kemp J T, Balasubramanian M K, Gould K L
Abstract excerpt
The organization of the actin cytoskeleton plays an integral role in cell morphogenesis of all eukaryotes. We have isolated a temperature-sensitive mutant in Schizosaccharomyces pombe, wat1-1, in which acting patches are delocalized, resulting in an elliptically shaped cell phenotype. Molecular cloning and DNA sequencing of wat1+ showed that the gene encodes a 314 residue protein containing WD-40 repeats. Cells...
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