Article
Linkage and physical mapping of X-linked lissencephaly/SBH (XLIS): a gene causing neuronal migration defects in human brain.
Human molecular genetics - 1 Apr 1997
Ross M E, Allen K M, Srivastava A K, Featherstone T, Gleeson J G, Hirsch B, Harding B N, Andermann E, Abdullah R, Berg M, Czapansky-Bielman D, Flanders D J, Guerrini R, Motté J, Mira A P, Scheffer I, Berkovic S, Scaravilli F, King R A, Ledbetter D H, Schlessinger D, Dobyns W B, Walsh C A
Abstract excerpt
While disorders of neuronal migration are associated with as much as 25% of recurrent childhood seizures, few of the genes required to establish neuronal position in cerebral cortex are known. Subcortical band heterotopia (SBH) and lissencephaly (LIS), two distinct neuronal migration disorders producing epilepsy and variable cognitive impairment, can be inherited alone or together in a single pedigree. Here we...
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