Article
Intracellular generation of superoxide by copper sulphate in Escherichia coli.
Mutation research - 17 Mar 1997
Kimura T, Nishioka H
Abstract excerpt
Oxidative stress exerted by superoxide-generating agents such as paraquat triggers induction of the soxRS regulon of E. coli. In the system, SoxR protein is the superoxide-sensitive activator of the soxS gene. We found that copper sulphate (CuSO4) is a powerful inducer of soxS in a manner tightly dependent on both a functional soxR gene and the presence of molecular oxygen. E. coli strain lacking either...
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