Article
Functional analysis of mutated purine-cytosine permease from Saccharomyces cerevisiae. A possible role of the hydrophilic segment 371-377 in the active carrier conformation.
The Journal of biological chemistry - 11 Apr 1997
Ferreira T, Brèthes D, Pinson B, Napias C, Chevallier J
Abstract excerpt
The purine-cytosine permease (PCP) is an active transporter located in the plasma membrane of the yeast Saccharomyces cerevisiae. This protein mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation in the cell by using an electrochemical potential difference in proton as t...
Topics
- Alleles
- Carrier Proteins
- Hydrogen-Ion Concentration
- Hypoxanthine
- Kinetics
- Membrane Transport Proteins
- Nucleobase Transport Proteins
- Point Mutation
- Protein Conformation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins