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Article

Nuclear Envelope Protein Autoantibodies in Primary Biliary Cirrhosis

1 Jan 1997

Abstract excerpt

A subset of patients with primary biliary cirrhosis (PBC) have autoantibodies directed against nuclear envelope proteins. The major autoantigen is gp210, a 210 kilodalton (kD) transmembrane protein of the nuclear pore complex, that is recognized by antibodies in approximately 25% of patients. The predominant epitope in gp210 that is recognized by most of the autoantibodies is a 15 amino acid stretch in the...

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PMID: 9089913
DOI: 10.1055/s-2007-1007185

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