Article
Determination of interferon-alpha2 allele composition in the genomic DNA from healthy volunteers and leukemic patients in Japan.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 1997
Kita M, Tanaka K, Uoshima N, Kobayashi Y, Ozawa M, Kondo M, Imanishi J
Abstract excerpt
The three interferon-alpha2 (IFN-alpha2) sequences identified to date differ from each other in just two nucleotide positions, both of which result in changes in amino acids. Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c...
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