Article
Interferon-alpha 2 variants in the human genome.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Apr 1995
Lee N, Ni D, Brissette R, Chou M, Hussain M, Gill D S, Liao M J, Testa D
Abstract excerpt
Variants of human leukocyte interferon alpha 2 (IFN-alpha 2a, alpha 2b, and alpha 2c) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. As a result of these nucleotide variations, the DNA sequences of the three variants can be distinguished by selective restriction enzyme analysis. Human genomic DNA obtained from over 28,000 normal healthy individuals was used as...
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