Evidence that two independent host genes influence the severity of tissue damage and susceptibility to acute pyelonephritis in murine systemic candidiasis.

doi:10.1006/mpat.1996.0102

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Article

Evidence that two independent host genes influence the severity of tissue damage and susceptibility to acute pyelonephritis in murine systemic candidiasis.

Microbial pathogenesis - 1 Mar 1997

Ashman R B, Fulurija A, Papadimitriou J M

Abstract excerpt

Tissue damage in the kidney and brain after systemic infection with Candida albicans was examined in recombinant inbred strains (AKXL) derived from AKR and C57/L progenitors. Nine of the 15 strains showed mild (C57/L-like) tissue damage. Of the remainder, two strains developed lesions comparable...

Topics

Alleles
Animals
Brain
Candidiasis
Complement System Proteins
Female
Genetic Predisposition to Disease
Hemolysis
Kidney
Mice
Mice, Inbred AKR
Mice, Inbred C57BL
Mice, Mutant Strains

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