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Article

Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments.

Human molecular genetics - 1 Nov 1998

Goncz K K, Kunzelmann K, Xu Z, Gruenert D C

Abstract excerpt

Recent studies have reported that mutant genomic cystic fibrosis (CF) transmembrane conductance regulator ( CFTR ) sequences can be corrected in transformed CF airway epithelial cell lines by targeted replacement with small fragments of DNA with wild-type sequence. To determine if the observed genotype modification following small fragment homologous replacement (SFHR) was limited to transformed CF cell lines,...

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Identifiers

PMID: 9811935
DOI: 10.1093/hmg/7.12.1913

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments.PMID 9811935Read ↗

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Targeted correction of a defective selectable marker gene in human epithelial cells by small DNA fragments.Semantic proximity Read ↗

DNA-PKcs Inhibition Improves Sequential Gene Insertion of the Full-Length <i>CFTR</i> cDNA in Airway Stem CellsSemantic proximity Read ↗

Creation and characterization of an airway epithelial cell line for stable expression of CFTR variantsSemantic proximity Read ↗

DNA-PKcs inhibition improves sequential gene insertion of the full-length CFTR cDNA in airway stem cellsSemantic proximity Read ↗

Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement.Semantic proximity Read ↗

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Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides.Semantic proximity Read ↗

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