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Article

Tazobactam is a potent inactivator of selected inhibitor-resistant class A β-lactamases

17 Jan 2006

Abstract excerpt

The beta-lactam beta-lactamase inhibitor combinations (ampicillin/clavulanate, ampicillin/sulbactam, ticarcillin/clavulanate and piperacillin/tazobactam) were tested against selected inhibitor-resistant class A beta-lactamases of the TEM and OHIO-1 varieties. Minimum inhibitor concentrations (MIC) revealed that the Escherichia coli DH5 alpha transconjugate strains that possessed the OHIO-1 beta-lactamase,...

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Identifiers

PMID: 9066111
DOI: 10.1111/j.1574-6968.1997.tb10267.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tazobactam is a potent inactivator of selected inhibitor-resistant class A β-lactamasesPMID 9066111Read ↗

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OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime.Semantic proximity Read ↗

Activity of ticarcillin/clavulanate and piperacillin/tazobactam (YTR 830; CL-298,741) against clinical isolates and against mutants derepressed for class I beta-lactamase.Semantic proximity Read ↗

Molecular basis of antibiotic resistance and β-lactamase inhibition by mechanism-based inactivators: perspectives and future directionsSemantic proximity Read ↗

Piperacillin-Tazobactam Resistance Mechanisms in <i>Escherichia coli</i> and Identification of a CTX-M-255 β-Lactamase Selectively Conferring Resistance to Penicillin/β-Lactamase Inhibitor CombinationsSemantic proximity Read ↗

Antibiotic resistance. Resistance mediated by inhibitor-resistant and extended-spectrum TEM and SHV beta-lactamases.Semantic proximity Read ↗

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