Article
Data-adaptive algorithms for calling alleles in repeat polymorphisms.
Electrophoresis - 1 Jan 1997
Stoughton R, Bumgarner R, Frederick W J, McIndoe R A
Abstract excerpt
Data-adaptive algorithms are presented for separating overlapping signatures of heterozygotic allele pairs in electrophoresis data. Application is demonstrated for human microsatellite CA-repeat polymorphisms in LiCor 4000 and ABI 373 data. The algorithms allow overlapping alleles to be called correctly in almost every case where a trained observer could do so, and provide a fast automated objective alternative...
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