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A hybrid approach to increase the informedness of CE-based data using locus-specific thresholding and machine learning.

Forensic science international. Genetics - 1 Jul 2018

Marciano Michael A, Williamson Victoria R, Adelman Jonathan D

Abstract excerpt

The interpretation of genetic profiles require a robust and reliable method to discriminate true allelic information from noise, regardless of the instrumentation or methods used. Traditionally, static peak detection thresholds (analytical thresholds) have been applied to capillary electrophoresis generated data to distinguish the true allelic peaks from noise. While the rigid nature of these thresholds attempts...

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PMID: 29627762
DOI: 10.1016/j.fsigen.2018.03.017

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