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Article

Molecular basis of asymptomatic beta-thalassemia major in an African American individual.

American journal of medical genetics - 17 Mar 1997

Ballas S K, Cai S P, Gabuzda T, Chehab F F

Abstract excerpt

The beta-thalassemia syndromes are a heterogeneous group of genetic disorders characterized by reduced or absent expression of the beta-globin gene. To date, over 300 beta-thalassemia alleles have been characterized in or around the beta-globin region. Thalassemia major is severe anemia necessitating chronic blood transfusions, splenectomy, iron chelation therapy, and bone marrow transplantation. Usually...

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PMID: 9056561

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