Article
Inhibitory effects of relaxin on cardiac fibroblast-to-myofibroblast transition: an electrophysiological study.
Experimental physiology - 1 Jun 2015
Squecco Roberta, Sassoli Chiara, Garella Rachele, Chellini Flaminia, Idrizaj Eglantina, Nistri Silvia, Formigli Lucia, Bani Daniele, Francini Fabio
Abstract excerpt
NEW FINDINGS: What is the central question of this study? Fibroblast-to-myofibroblast transition is a key mechanism in the reparative response to tissue damage, but myofibroblast persistence in the wound leads to fibrosis and organ failure. The role of relaxin as an antifibrotic agent capable of counteracting the acquisition of biophysical features of differentiated myofibroblasts deserves further investigation....
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