Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect.

doi:10.1002/(SICI)1096-9926(199611)54:5<230::AID-TERA3>3.0.CO;2-3

Back to search

Article

Exencephaly and cleft cerebellum in SELH/Bc mouse embryos are alternative developmental consequences of the same underlying genetic defect.

Teratology - 1 Nov 1996

Gunn T M, Juriloff D M, Harris M J

Abstract excerpt

SELH/Bc inbred mice have ataxia in 5-10% of young adults and exencephaly in 10-20% of newborns. SELH/Bc mice also have a high rate of spontaneous mutation and therefore it could not be assumed that these two abnormalities share the same genetic cause. Previously, we have shown that the liability...

Topics

Animals
Brain
Cerebellum
Embryonic and Fetal Development
Female
Mice
Mice, Inbred Strains
Mutation
Pregnancy

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.