Article
Mitogenic activity but not phenotype expression of rat osteoprogenitor cells in response to IGF-I is impaired in aged rats.
Mechanisms of ageing and development - 29 Nov 1996
Tanaka H, Liang C T
Abstract excerpt
The age-related deficit in the dose response of osteoprogenitor cells to IGF-I was further investigated. As expected, the effective dose, but not the maximal effect, was shifted two orders of magnitude higher in old cells. In this paper, we examined whether this age-deficit can be attributed to an alteration in the expression and binding kinetics of IGF-I receptor. We showed that the levels of IGF-I receptor mRNA...
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