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Article

Construction of adenovirus vectors through Cre-lox recombination

1 Mar 1997

Abstract excerpt

Two barriers prevent adenovirus-based vectors from having wide application. One is the difficulty of making new adenoviruses, and the second is the strong immunological reaction to viral proteins. Here we describe uses of Cre-lox recombination to overcome these problems. First, we demonstrate a simple method for constructing E1-substituted adenoviruses. Second, we demonstrate a method to construct adenovirus...

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Identifiers

PMID: 9032314
DOI: 10.1128/jvi.71.3.1842-1849.1997

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