Transcriptional activation of mucin by <i>Pseudomonas aeruginosa</i> lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease

Abstract excerpt

An unresolved question in cystic fibrosis (CF) research is how mutations of the CF transmembrane conductance regulator, a Cl ion channel, cause airway mucus obstruction leading to fatal lung disease. Recent evidence has linked the CF transmembrane conductance regulator mutation to the onset and persistence of Pseudomonas aeruginosa infection in the airways, and here we provide evidence directly linking P....

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