Article
Development of a sensitive PCR to detect allele loss in a model hematopoietic neoplasm.
PCR methods and applications - 1 Aug 1994
Fairman J, Claxton D, Williman C L, Deisseroth A B, Nagarajan L
Abstract excerpt
Loss or gain of an entire chromosome and interstitial deletions or amplifications are hallmarks of several hematopoietic neoplasms. These chromosomal anomalies can be identified by conventional cytogenetic analysis of bone marrow aspirates. We have developed a PCR-based assay to detect loss of chromosome 5q31 loci, in the model system of myeloid disorders with the 5q- chromosome (interstitial deletion of 5q), by...
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