Article
Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
Molecular biology of the cell - 1 Jan 1997
Kominami K, Okura N, Kawamura M, DeMartino G N, Slaughter C A, Shimbara N, Chung C H, Fujimuro M, Yokosawa H, Shimizu Y, Tanahashi N, Tanaka K, Toh-e A
Abstract excerpt
Nin1p, a component of the 26S proteasome of Saccharomyces cerevisiae, is required for activation of Cdc28p kinase at the G1-S-phase and G2-M boundaries. By exploiting the temperature-sensitive phenotype of the nin1-1 mutant, we have screened for genes encoding proteins with related functions to Nin1p and have cloned and characterized two new multicopy suppressors, SUN1 and SUN2, of the nin1-1 mutation. SUN1 can...
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