Article
Immunocytochemical phenotyping of disseminated tumor cells in bone marrow by uPA receptor and CK18: investigation of sensitivity and specificity of an immunogold/alkaline phosphatase double staining protocol.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Feb 1997
Allgayer H, Heiss M M, Riesenberg R, Babic R, Jauch K W, Schildberg F W
Abstract excerpt
Phenotyping of cytokeratin (CK)18-positive cells in bone marrow is gaining increasing importance for future prognostic screening of carcinoma patients. Urokinase-type plasminogen activator receptor (uPA-R) is one example of a potential aggressive marker for those cells. However, a valid and reliable double staining method is needed. Using monoclonal antibodies against uPA-R and CK18, we modified an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.