Article
Random sequence phosphorothioate oligonucleotides evoke dramatic phenotypic alterations in cardiac myocyte cultures.
Antisense & nucleic acid drug development - 1 Jan 1996
Davis D L, Doten I C, Barald K F, Axelrod D, Burch J B
Abstract excerpt
Cardiac myocytes displayed modest and uncoordinated contractile activity regardless of whether they are cultured in the presence or absence of unmodified random sequence oligonucleotides (oligos), as expected. Much to our surprise, however, when cardiac myocytes were cultured in the presence of random sequence phosphorothioate (PS) oligos, they reorganized into cablelike aggregates and displayed surging and...
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