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Article

Chimeric and humanized antibodies with specificity for the CD33 antigen

1 Feb 1992

Abstract excerpt

L and H chain cDNAs of M195, a murine mAb that binds to the CD33 Ag on normal and leukemic myeloid cells, were cloned. The cDNAs were used in the construction of mouse/human IgG1 and IgG3 chimeric antibodies. In addition, humanized antibodies were constructed which combined the complementarity-determining regions of the M195 antibody with human framework and constant regions. The human framework was chosen to...

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PMID: 1737932
DOI: 10.4049/jimmunol.148.4.1149

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