Induction of heat shock proteins by abnormal proteins results from stabilization and not increased synthesis of sigma 32 in Escherichia coli.

Abstract excerpt

Accumulation of abnormal proteins in cells of bacteria or eukaryotes can induce synthesis of a set of heat shock proteins. We examined such induction following addition of azetidine (a proline analog) or synthesis of a heterologous protein (human prourokinase) in Escherichia coli. Synthesis of heat shock proteins under these conditions increased almost immediately and continued with increasing rates until it...

Topics

• Azetidines
• Bacterial Proteins
• Chaperonin 60
• Escherichia coli
• Escherichia coli Proteins
• Gene Expression Regulation, Bacterial
• HSP70 Heat-Shock Proteins
• Heat-Shock Proteins
• Humans
• Mutation
• Recombinant Fusion Proteins