Article
High frequency of a deletion polymorphism of the angiotensin-converting enzyme gene in asthma.
The Journal of allergy and clinical immunology - 1 Jan 1997
Benessiano J, Crestani B, Mestari F, Klouche W, Neukirch F, Hacein-Bey S, Durand G, Aubier M
Abstract excerpt
BACKGROUND: An insertion-deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been shown to be associated with levels of ACE. Because ACE is heavily expressed in the lungs and plays a key role in the metabolism of angiotensin II and bradykinin, which are potentially involved in the pathogenesis of asthma, we tested the hypothesis of an association between the polymorphism of the ACE gene and...
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